Utilizing animal models to monitor ECG in Post Traumatic Epi | 121139

सर्जरी: वर्तमान शोध

आईएसएसएन - 2161-1076


Utilizing animal models to monitor ECG in Post Traumatic Epilepsy

John Klausner

Studies on Post-Traumatic Epilepsy (PTE) in large animal models are scarce. Neocortical PTE has been better understood thanks to recent developments in neocortical microscopy. Nevertheless, it is incredibly difficult to induce believable neocortical PTE in rodents. Hence, large animal models that expand neocortical PTE can also offer helpful insights that may yet be better suited to human patients. Long-term video EEG recording is necessary because to the lengthy latent periods of gyrencephalic species. Here, we provide documentation of a fully subcutaneous EEG implant in freely moving pigs for up to fourteen months during epileptogenesis following bilateral cortical effect accidents or phantom surgical procedures. The advantages of this device include the availability of an easily installed, commercially available device, a low failure rate following surgical EEG implantation, radiotelemetry that allows continuous tracking of freely moving animals, excellent video to EEG synchronisation, and a high signal to noise ratio. The accretion of cranium bone, which entirely encased a portion of cranial screws and EEG electrodes, and the inability to arrange the EEG electrode array are the hazards of this device on this species and age.