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Effects of 1,8-Cineole on the Activity of Cyclooxygenase and | 43599

प्राकृतिक उत्पाद रसायन एवं अनुसंधान

आईएसएसएन - 2329-6836

अमूर्त

Effects of 1,8-Cineole on the Activity of Cyclooxygenase and Cyclooxygenase 1 and Cyclooxygenase 2 Isoforms

Beer AM, Zagorchev P, Draganova-Filipova M and Lukanov J

Purpose: The anti-inflammatory effects of 1,8‑cineole (eucalyptol) in the treatment of acute bronchitis and treatment of chronic airway diseases like asthma as well as hay fever have been observed in clinical practice for some time. The anti-inflammatory effect has been proven in numerous studies.

Material and methods: The effect of 1,8-cineole on the activity of cyclooxygenase and its two isoforms (COX‑1 and COX‑2) were analysed and compared with the effects of indomethacin and celecoxib.

Results: The ratio between the concentrations required to achieve 50% inhibition of COX‑1 and COX‑2 isoform activity was found to be 73.5.

Discussion: For indomethacin, the ratio is 9.71 and for celecoxib 79.5. For indomethacin, it is about 10 times less than that of 1,8‑cineole.

Conclusion: The present study provides useful data suggesting that 1,8‑cineole is a specific COX‑2 blocker.

अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।